The use of lepirudin in haemodialysis complicated with heparin-induced thrombocytopenia type II (HIT II)--dosage monitoring.

نویسندگان

  • Theodoros Ioannis Kassimatis
  • Theofanis Apostolou
  • Theodoros Theodoridis
  • Mahmut El Ali
  • Valsamakis Hadjiconstantinou
چکیده

1. Bettinelli A, Giovanni M, Bianchetti MG et al. Use of calcium excretion values to distinguish two forms of primary renal tubular hypokalemic alkalosis: Bartter and Gitelman syndrome. J Pediatr 1992; 120: 38–43 2. Lin S-H, Cheng N-L, Hsu Y-J, Halperin ML. Intrafamilial phenotype variability in patients with Gitelman syndrome having the same mutations in their thiazide-sensitive sodium/chloride cotransporter. Am J Kidney Dis 2004; 43: 304–312 3. Kamel KS, Harvey E, Douek K, Halperin ML. Studies on the pathogenesis of hypokalemia in Gitelman’s syndrome: role of bicarbonaturia and hypomagnessemia. Am J Nephrol 1998; 18: 42–49 4. Takeuchi K, Kure S, Kato T et al. Association of a mutation in the thiazide-sensitive Na-Cl cotransporter with familial Gitelman’s syndrome. J Clin Endocr Metab 1996; 81: 4496–4499 5. Tajima T, Kobayashi Y, Abe S et al. Two novel mutations of thiazide-sensitive Na-Cl cotransporter (TSC) gene in two sporadic Japanese patients with Gitelman syndrome. Endocr J 2002; 49: 91–96 6. Tsukamoto T, Kobayashi T, Kawamoto K, Fukase M, Chihara K. Possible discrimination of Gitelman’s syndrome from Bartter’s syndrome by renal clearance study: report of two cases. Am J Kidney Dis 1995; 25: 637–641 7. Baehler RW, Work J, Kotchen TA, McMorrow G, Guthrie G. Studies on the pathogenesis of Bartter’s syndrome. Am J Med 1980; 69: 933–938 8. Uribarri J, Alverabga D, Oh MS, Kukar NM, Del Monte ML, Carroll HJ. Bartter’s syndrome due to a defect in salt reabsorption in the distal convoluted tubule. Nephron 1985; 40: 52–56 9. Stein JH. The pathogenetic spectrum of Bartter’s syndrome. Kidney Int 1985; 28: 85–93

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Our experience in three coronary patients with heparin induced thrombocytopenia type II, platelets

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Use of ecarin clotting time (ECT) with lepirudin therapy in heparin-induced thrombocytopenia and cardiopulmonary bypass.

Heparin-induced thrombocytopenia (HIT) is described as an allergy-like adverse reaction to heparin. It is a potentially severe complication of heparin therapy that can result in serious or life-threatening venous or arterial thromboembolic events. In the United States, lepirudin (Aventis Pharma AG, Strasbourg, France) is an approved therapy for anticoagulation in patients with HIT requiring ant...

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Anticoagulation in extracorporeal circulation using recombinant hirudin: a case report.

Heparin-induced thrombocytopenia (HIT) is a severe complication following the application of heparin; antibodies against complexes of heparin and PDF4 initiate activation of platelets. This may lead to massive thrombembolism, which is associated with a slight and transient drop of platelets in HIT I or a drop below 50% after approximately 5 days in HIT II. Further administration of heparin has ...

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Heparin induced thrombocytopenia

Abstract Background and Objectives Heparin is still a commonly used anticoagulant in prophylaxis and treatment of thromboembolic events. Heparin-induced thrombocytopenia (HIT) is a life-threating adverse drug reaction of heparin. The diagnosis of HIT is made based on two important criteria, firstly clinical evaluation and secondly laboratory testing. In this comprehensive review, the authors w...

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عنوان ژورنال:
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

دوره 21 11  شماره 

صفحات  -

تاریخ انتشار 2006